教师简介
许可,男,副教授,博士研究生,邮箱:xuke@tstc.edu.cn。
教育经历
2014/09-2018/06北京理工大学 生物化工 博士
2012/09-2014/09北京理工大学 生物学 硕士
2002/09-2006/07燕山大学 生物工程 工学学士
工作经历
2020/12-至今 唐山师范学院生命科学系
2018/11-2020/11清华大学化工系 博士后/助理研究员
2006/05-2011/03北京科兴生物制品有限公司
教学情况
微生物学 劳动教育 大学生创业基础
在研项目
1. 酿酒酵母胁迫信号级联传导与阻断调控的分子机制(2021- 2024)项目负责人国家自然科学基金面上项目(63万)22078171
2. 多重抗逆酿酒酵母的构建(2021- 2024)项目负责人 河北省重点研发计划(80万)21374301D
3. 多重耐受性酿酒酵母的构建与耐受机理研究(2021- 2024)项目负责人 唐山市科技计划项目(8万)21130201C
4. Cre-loxP重组构建多重耐受酵母菌株(2022 - 2024)项目负责人 唐山师范学院校内科研基金项目(8万)2022B09
5. 山楂酸糖基化衍生物的生物合成及其抗乳腺癌作用研究(2022-2024)参与河北省自然基金精准医学项目(30万)B2022105015
6. 抗新冠肺炎稀有甘草三萜分子设计与生物合成(2021-2024)参与 北京市自然基金专项(30万)M21010
近五年论著文章:
1. Xu K, Qin L, Bai W, et al. Multi-level defense system (MDS) relieves multiple stresses for economically boosting ethanol production of industrial Saccharomyces cerevisiae [J].ACS Energy Letters, 2020, 5: 572-582.(SCI一区top)
2. Xu K, Lv B, Huo Y X, et al. Toward the lowest energy consumption and emission in biofuel production: combination of ideal reactors and robust hosts [J].Current Opinion in Biotechnology, 2018, 50: 19-24.(SCI一区top)
3. Xu K, Zhao Y, NadeemA, et al. O-glycosyltransferases from Homo sapienscontributes to the biosynthesis of Glycyrrhetic Acid 3-O-mono-β-D-glucuronide and Glycyrrhizin in Saccharomyces cerevisiae[J].Synthetic and Systems Biotechnology, 2021,6(3):173-179.(SCI二区)
4. Xu K, Gao L , Jalees U , et al. Improving the thermo-tolerance of yeast base on the antioxidant defense system[J].Chemical Engineering Science.2018, 175: 335-342.(SCI二区top)
5. Xu K, Yu L, Bai W, et al. Construction of thermo-tolerant yeast based on an artificial protein quality control system (APQC) to improve the production of bio-ethanol [J].Chemical Engineering Science.2018, 177: 410-416.(SCI二区top)
6. Xu K, Lee Y, Li J, et al. Resistance mechanisms and reprogramming of microorganisms for efficient biorefinery under multiple environmental stresses[J].Synthetic and Systems Biotechnology, 2019, 4(2): 92-98.(SCI二区)
7. Zhang M, Zhang H, He Y, Wu Z., & Xu, K*. Improving thermo-tolerance of Saccharomyces cerevisiae by precise regulation of the expression of small HSP[J]. RSC advances, 2023, 13(51): 36254-36260.(SCI三区)
8. Hu F, Chen J, Zhang Y, ... Xu K* & Cai H. Novel Biotransformation of Maslinic Acid to MA-2-O-β-D-Glucoside by UDP-Glycosyltransferases from Bacillus subtilis[J]. Catalysts, 2022, 12(8): 884. (SCI三区)
9. Qin L, Liu X, Xu K, et al. Mining and design of biosensors for engineering microbial cell factory[J]. Current Opinion in Biotechnology, 2022, 75: 102694.(SCI一区top)
10. Nadeem A, Xu K, Wang J, et al. Novel catalytic glycosylation of Glycyrrhetinic acid by UDP-Glycosyltransferases fromBacillus subtilis[J].Biochemical Engineering Journal, 2020,162: 107723.(SCI三区)
11. Gao X, Xu K, Ahmad N, et al. Recent advances in engineering of microbial cell factories for intelligent pH regulation and tolerance[J].Biotechnology Journal, 2021: 2100151.(SCI二区)
12. 许可*, 张运峰, 秦磊, 等. 耐热基因线路随机组装构建高版本耐热酿酒酵母. [J].中国科学: 生命科学, 2023, 53: 399–407
13. 许可,王靖楠,李春. 智能抗逆微生物细胞工厂与绿色生物制造[J].合成生物学, 2020,1(4):407-418.