教师风采

许可

发布者:  时间:  浏览:2021-03-19 16:39:42

教师简介

许可,男,讲师,博士研究生,邮箱:xuke528@tsinghua.edu.cn

教育经历

2014/09-2018/06北京理工大学 生物化工 博士

2012/09-2014/09北京理工大学 生物学 硕士

2002/09-2006/07燕山大学 生物工程 工学学士

工作经历

2020/12-至今唐山师范学院生命科学系

2018/11-2020/11清华大学化工系 博士后/助理研究员

2014/11-2018/06中粮营养健康研究院 项目合作

2006/05-2011/03北京科兴生物制品有限公司

教学情况

微生物学、农学微生物学、生物化学实验

在研项目

1. 酿酒酵母胁迫信号级联传导与阻断调控的分子机制(2021- 2024)项目负责人国家自然科学基金面上项目(63万)22078171

2. 多重抗逆酿酒酵母的构建(2021- 2024)项目负责人河北省重点研发计划(80万)21374301D

3. 多重耐受性酿酒酵母的构建与耐受机理研究(2021- 2024)项目负责人唐山市科技计划项目(8万)21130201C

4. Cre-loxP重组构建多重耐受酵母菌株(2022 - 2024)项目负责人唐山师范学院校内科研基金项目(8万)2022B09

5. 合成植物天然产物的微生物细胞工厂构建及应用示范(2020- 2024)参与国家重点研发计划项目(2400万)2018YFA0901800

6. 抗新冠肺炎稀有甘草三萜分子设计与生物合成(2021-2024)参与北京市自然基金专项(30万)M21010

结题项目

1. 酿酒酵母发酵产乙醇过程中的胁迫级联放大途径及其调控(2019 - 2020)项目负责人博士后基金面上一等资助(12万)2019M650031

2. 酿酒酵母耐热耐乙醇性能改造(2015- 2020)项目负责人企业合作项目(中粮)(100万)20151641161

3. 微生物耐热元器件的构建及其与底盘宿主的适配性研究(2014 - 2018)排名第二国家自然科学基金面上项目(68万)21376028

获奖情况

1. 2014年国际遗传工程机器竞赛(iGEM)金奖(MIT主办)

2. 2015年国际遗传工程机器竞赛(iGEM)金奖,Nominated for Best New Appliation Project(MIT主办)

3. 2013-2014年,2015-2016年,2016-2017年优秀研究生

4. 2018届北京理工大学优秀毕业生

论著文章:

  1. Xu K, Qin L, Bai W, et al. Multi-level defense system (MDS) relieves multiple stresses for economically boosting ethanol production of industrial Saccharomyces cerevisiae [J].ACS Energy Letters, 2020, 5: 572-582.If=23.101(SCI一区top)

  2. Xu K, Lv B, Huo Y X, et al. Toward the lowest energy consumption and emission in biofuel production: combination of ideal reactors and robust hosts [J].Current Opinion in Biotechnology, 2018, 50: 19-24.If=9.740SCI一区top

  3. Xu K,Zhao Y,NadeemA, et al. O-glycosyltransferases from Homo sapienscontributes to the biosynthesis of Glycyrrhetic Acid 3-O-mono-β-D-glucuronide and Glycyrrhizin in Saccharomyces cerevisiae[J].Synthetic and Systems Biotechnology, 2021,6(3):173-179.If=4.708SCI二区

  4. Xu K, Gao L , Jalees U , et al. Improving the thermo-tolerance of yeast base on the antioxidant defense system[J].Chemical Engineering Science.2018, 175: 335-342.If=4.311SCI二区top

  5. Xu K, Yu L, Bai W, et al. Construction of thermo-tolerant yeast based on an artificial protein quality control system (APQC) to improve the production of bio-ethanol [J].Chemical Engineering Science.2018, 177: 410-416.If=4.311SCI二区top

  6. Xu K, Lee Y S, Li J, et al. Resistance mechanisms and reprogramming of microorganisms for efficient biorefinery under multiple environmental stresses[J].Synthetic and Systems Biotechnology, 2019, 4(2): 92-98.If=4.708SCI二区top

  7. Li X1,Xu K1, Fu W, et al. Simultaneous in-situ excess sludge reduction and removal of organic carbon and nitrogen by a pilot-scale continuous aerobic–anaerobic coupled (CAAC) process for deeply treatment of soybean wastewater [J].Biochemical Engineering Journal, 2014, 85: 30-37.If=3.978SCI二区 共同一作

  8. Qin L, Liu X,Xu K, et al. Mining and design of biosensors for engineering microbial cell factory[J]. Current Opinion in Biotechnology, 2022, 75: 102694.If=9.740SCI一区top

  9. Nadeem A,Xu K, Wang J, et al. Novel catalytic glycosylation of Glycyrrhetinic acid by UDP-Glycosyltransferases fromBacillus subtilis[J].Biochemical Engineering Journal, 2020,162: 107723.If=3.978SCI二区

  10. Gao X,Xu K, Ahmad N, et al. Recent advances in engineering of microbial cell factories for intelligent pH regulation and tolerance[J].Biotechnology Journal, 2021: 2100151.If=4.677SCI二区

  11. Huangfu J, Kim H S,Xu K, et al. Omics Analysis Reveals the Mechanism of Enhanced Recombinant Protein Production Under Simulated Microgravity[J].Frontiers in Bioengineering and Biotechnology, 2020, 8: 30.If=3.644SCI三区

  12. Jalees U H, Imdaad K, Aamir R,Xu K, et al. Engineered Saccharomyces cerevisiae for the De Novo Synthesis of the Aroma Compound Longifolene[J].Chemical Engineering Science, 2020,226: 115799.If=4.311SCI二区top

  13. Qin L, Dong S, Yu J,Xu K, et al. Stress-driven dynamic regulation of multiple tolerance genes improves robustness and productive capacity of Saccharomyces cerevisiae in industrial lignocellulose fermentation[J].Metabolic Engineering, 2020. 61: 160-170.If=9.783SCI一区top

  14. Li C , Gao X , Peng X...Xu K, et al. Intelligent microbial cell factory with genetic pH shooting (GPS) for cell self-responsive base/ acid regulation[J].Microbial Cell Factories, 2020, 19(1).If=5.328SCI

  15. 许可,吕波,李春.无细胞的合成生物技术——多酶催化与生物合成[J].中国科学(化学), 2015, 045(005):429-437.核心期刊

  16. 许可,王靖楠,李春.智能抗逆微生物细胞工厂与绿色生物制造[J].合成生物学,2020,1(4):407-418.核心期刊

  17. 高小朋,何猛超,许可*.工业微生物发酵过程中pH调控研究进展[J].中国生物工程杂志, 2020, 40(6): 93-99.(通讯作者核心期刊

  18. 俞杰,秦磊,许可,等.细胞工厂氧化还原状态的荧光探针检测与调控[J].生物加工过程, 2020(1):60-69.核心期刊

获得专利:

1. 授权专利:一种提高酿酒酵母耐热性的分子调控方法(ZL103820345A)